Development changeMay 21, 2026
TRIUMPH-1 delivered positive pivotal Phase 3 results
Trial readout · Phase 3
Lilly reported positive topline results from TRIUMPH-1, providing the first pivotal Phase 3 obesity readout for retatrutide while the drug remained investigational.
Research sourcePublished 2026
TRIUMPH-1 Phase 3 Results
Human intervention · Industry Phase 3 report
Company-reported TRIUMPH-1 results provide late-stage human evidence for retatrutide and move the evidence base beyond early clinical development.
Development changeJun 26, 2023
Phase 2 obesity trial published
Trial readout · Phase 2
The randomized Phase 2 obesity trial was published online in the New England Journal of Medicine, establishing direct mid-stage human efficacy and safety evidence for retatrutide.
Research sourcePublished 2023
Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Human intervention · Phase 2 randomized trial
This randomized Phase 2 trial established direct human efficacy and safety evidence for retatrutide as a triple GIP, GLP-1, and glucagon receptor agonist.