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CJC-1295 Reconstitution Calculator & Guide
Long-Acting Growth Hormone-Releasing Hormone Analog
CJC-1295 is an investigational growth hormone-releasing hormone (GHRH) analog studied for its ability to increase endogenous growth hormone and IGF-1 signaling. Human research is limited, and CJC-1295 is not an FDA-approved medication. This page explains the original long-acting CJC-1295 compound, the common 'with DAC' and 'no DAC' terminology, available human evidence, safety and anti-doping status, and educational reconstitution math.
Evidence Snapshot
CJC-1295 research at a glance
Standardized regulatory and evidence context so research compounds, investigational drugs, and approved medications are not treated as if they have the same level of human evidence.
Regulatory status
Not FDA-approvedDevelopment / evidence stage
Phase 2 (historical)
Historical clinical development
Human evidence level
Human pharmacology / early clinicalPrimary mechanism
GHRH analog. The original studied CJC-1295 uses a Drug Affinity Complex to extend albumin binding and duration.
WADA context
Explicitly prohibited — S2Human intervention evidence
Human evidence is mainly pharmacokinetic/pharmacodynamic and does not establish bodybuilding, fat-loss, anti-aging, or recovery outcomes.
Human biology evidence
Small controlled human studies of the original long-acting CJC-1295 demonstrated prolonged increases in growth hormone and IGF-1 while preserving pulsatile GH secretion.
Variant matters
Important: the original human literature studied long-acting CJC-1295 with DAC. Products marketed as 'CJC-1295 No DAC' are generally discussed as Mod GRF 1-29 and do not share the same direct human evidence base.
Key takeaway
CJC-1295 has real human pharmacology data, but those data apply to the long-acting DAC compound and should not be generalized to online 'no DAC' products.
Evidence labels describe the research base and regulatory context; they are not treatment, dosing, or use recommendations. Review dates describe the last BACToBasics source check for this evidence summary. Anti-doping rules can change and should be verified with the applicable authority.
CJC-1295 Reconstitution Calculator
Enter the vial amount, liquid volume, and amount you want to calculate. BACToBasics will automatically calculate concentration, liquid volume, and U-100 syringe-unit equivalents.
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Calculator values are educational math inputs only. They are not recommended preparation amounts, doses, or use protocols.
CJC-1295 Reconstitution Math
Reconstitution math starts with the amount contained in the vial and the liquid volume used in the calculation. Dividing the vial amount by the liquid volume gives the resulting concentration.
Example vial amount
2 mg
| Liquid Volume | Calculation | Concentration |
|---|---|---|
| 1 mL | 2 mg ÷ 1 mL | 2 mg/mL |
| 2 mL | 2 mg ÷ 2 mL | 1 mg/mL |
| 3 mL | 2 mg ÷ 3 mL | 0.6667 mg/mL |
This table demonstrates concentration math only. The liquid volumes shown are examples for comparison and are not preparation recommendations.
More Reconstitution Tools
Need to compare different liquid volumes or convert between mg, mcg, mL, and U-100 units? Use the dedicated BACToBasics calculator tools.
What is CJC-1295?
CJC-1295 is a synthetic analog of growth hormone-releasing hormone, or GHRH. GHRH normally signals the pituitary gland to release growth hormone. The original CJC-1295 molecule was designed to resist rapid breakdown and to bind to circulating albumin, substantially extending its duration of action compared with native GHRH.
How does CJC-1295 work?
CJC-1295 acts as a GHRH-receptor agonist. By stimulating GHRH receptors in the pituitary, it can increase endogenous growth hormone secretion, which in turn can increase insulin-like growth factor 1 (IGF-1). This is different from administering growth hormone itself because CJC-1295 stimulates the body's own GH secretory pathway rather than directly supplying GH.
What have human studies shown?
The best-known human data come from small randomized studies published in 2006. In healthy adults, a single administration of long-acting CJC-1295 produced dose-dependent increases in mean growth hormone concentrations for six days or longer and increases in mean IGF-1 concentrations for roughly nine to eleven days. The estimated half-life was approximately 5.8 to 8.1 days. These studies primarily evaluated pharmacology and hormone levels rather than bodybuilding, anti-aging, or long-term clinical outcomes.
Does CJC-1295 preserve natural GH pulses?
A separate human study examined growth-hormone pulsatility after long-acting CJC-1295. Researchers found that pulsatile GH secretion persisted despite the prolonged GHRH stimulation. That finding is pharmacologically interesting, but it should not be interpreted as proof of improved body composition, performance, recovery, or longevity.
What does 'CJC-1295 with DAC' mean?
The original compound described in the scientific literature contains a reactive Drug Affinity Complex, commonly shortened to DAC, that allows the molecule to form a long-lasting bond with endogenous albumin. This albumin binding is central to the prolonged half-life reported in the original CJC-1295 studies. Online vendors often call this formulation 'CJC-1295 with DAC.'
What does 'CJC-1295 no DAC' mean?
The phrase 'CJC-1295 no DAC' is widely used online, but the terminology is inconsistent. Products marketed under that name are often described as shorter-acting modified GRF(1-29)-type peptides rather than the albumin-binding long-acting CJC-1295 studied in the original human trials. Because online naming can be inconsistent, a product label using 'CJC-1295 no DAC' should not automatically be assumed to represent the same compound studied in published CJC-1295 research.
CJC-1295 vs Ipamorelin
CJC-1295 and Ipamorelin act through different signaling pathways. CJC-1295 is a GHRH analog, while Ipamorelin is a growth hormone secretagogue that acts through the ghrelin receptor. They are frequently discussed together in online performance communities because both can influence GH secretion, but their combination has not been established as a safe or effective bodybuilding or anti-aging treatment in robust clinical trials.
Does CJC-1295 build muscle or reduce body fat?
Claims about muscle gain, fat loss, recovery, sleep, and anti-aging are common online, but the human CJC-1295 studies were not designed to establish these outcomes. The published human evidence primarily demonstrates effects on growth hormone and IGF-1 concentrations. Changes in hormone levels should not be treated as proof of meaningful improvements in muscle mass, fat loss, athletic performance, or longevity.
What is known about CJC-1295 safety?
Human safety data are limited. Early short-duration studies reported that the original long-acting CJC-1295 was generally tolerated in the small number of healthy adults studied, but that evidence does not establish long-term safety. FDA has since identified serious adverse events associated with CJC-1295, including increased heart rate and a systemic vasodilatory reaction, and has also raised concerns about immunogenicity, peptide-related impurities, and active-ingredient characterization in compounded products.
Is CJC-1295 FDA-approved?
No. CJC-1295 is not an FDA-approved medication. FDA has reviewed CJC-1295 in the context of bulk drug substances proposed for compounding and states that available clinical data are limited. Products sold online as CJC-1295 should not be treated as equivalent to an FDA-approved pharmaceutical product.
Is CJC-1295 banned in competitive sports?
Yes. The World Anti-Doping Agency's 2026 Prohibited List specifically names CJC-1295 under growth hormone-releasing factors. It is prohibited at all times for athletes subject to WADA rules.
Research CJC-1295 vs a regulated medication
There is no FDA-approved CJC-1295 product with a standardized commercial formulation, approved indication, validated dosing regimen, or FDA-reviewed manufacturing process. Products advertised online as research CJC-1295 may differ in identity, concentration, purity, sterility, and formulation, particularly because 'with DAC' and 'no DAC' naming is not used consistently across sellers.
CJC-1295 reconstitution math
Reconstitution calculations depend on the labeled amount in a vial and the liquid volume used. As a mathematical example, a 2mg vial combined with 2mL of liquid produces a concentration of 1mg per mL, which is the same as 1,000mcg per mL. BACToBasics uses examples like this only to demonstrate concentration, liquid-volume, and U-100 syringe-unit calculations rather than to recommend a CJC-1295 preparation or dosing protocol.
Explore more about CJC-1295
16 linksComparisons, research records, development tracking, blends, and related guides are available here when you want to go deeper.
Explore more about CJC-1295
16 linksComparisons, research records, development tracking, blends, and related guides are available here when you want to go deeper.
Compare CJC-1295
Direct comparison pages are selected from the indexable BACToBasics comparison catalog and update automatically as that catalog grows.
CJC-1295 vs Ipamorelin
Compare CJC-1295, Ipamorelin using the same evidence dataset.
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ComparisonTesamorelin vs CJC-1295
Compare Tesamorelin, CJC-1295 using the same evidence dataset.
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ComparisonTesamorelin vs CJC-1295 vs Ipamorelin
Compare Tesamorelin, CJC-1295, Ipamorelin using the same evidence dataset.
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Research, updates & development
Jump from the guide into the public update timeline, compound-specific research records, and clinical-development tracker without searching again.
CJC-1295 research & development updates
Open the public timeline of sourced research records and material development changes tracked by BACToBasics.
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ResearchCJC-1295 research sources
Open 2 curated research records for CJC-1295.
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DevelopmentCJC-1295 clinical development
Phase 2 (historical) · Historical clinical development. Historical Phase 2 program; ClinicalTrials.gov record NCT00267527 is terminated.
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Blend guides containing CJC-1295
These pages are derived from blend component metadata, so a new blend automatically becomes discoverable from each linked component guide.
CJC-1295 + Ipamorelin
Fixed-ratio vial-label math for a CJC-1295 + Ipamorelin blend.
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Blend guideCJC-1295 + GHRP-2
Label math for CJC-1295 + GHRP-2 blends with an explicit No DAC naming warning.
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Blend guideCJC-1295 + GHRP-6
Label math for CJC-1295 + GHRP-6 blends with formulation identity kept explicit.
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Related peptide guides
Related guides are ranked from shared comparison pages, shared blend pages, and peptide category rather than a hand-maintained link list.
Ipamorelin guide & calculator
Growth Hormone & Performance · Growth Hormone Secretagogue / Ghrelin Receptor Agonist
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Peptide guideTesamorelin guide & calculator
Growth Hormone & Performance · Growth Hormone-Releasing Hormone Analog
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Peptide guideGHRP-2 guide & calculator
Growth Hormone & Performance · Pralmorelin / GH-Releasing Peptide-2
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Peptide guideGHRP-6 guide & calculator
Growth Hormone & Performance · Growth Hormone-Releasing Peptide-6
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Relevant glossary concepts
Definitions are matched against the guide's structured title, subtitle, description, and educational sections.
FDA-Approved
A status indicating that the FDA has approved a specific drug product for one or more labeled uses after reviewing the required evidence and manufacturing information.
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GlossaryMilliliter (mL)
A metric unit of liquid volume equal to one-thousandth of a liter.
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GlossaryAgonist
A molecule that binds to a receptor and activates signaling through that receptor.
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CJC-1295 FAQ
Tap a question to expand only the answer you want to read.
Is CJC-1295 FDA-approved?
No. CJC-1295 is not an FDA-approved medication. FDA has stated that available clinical data are limited and has identified safety and product-quality concerns in the compounding context.
What is the difference between CJC-1295 with DAC and without DAC?
The original CJC-1295 studied in the scientific literature uses an albumin-binding Drug Affinity Complex, or DAC, that creates a prolonged half-life. The phrase 'CJC-1295 no DAC' is commonly used online for shorter-acting GHRH analog products, but naming is inconsistent and those products should not automatically be assumed to be the same compound studied in the original CJC-1295 trials.
How long does CJC-1295 last?
In published studies of the original long-acting CJC-1295 compound, the estimated half-life was approximately 5.8 to 8.1 days. That figure should not be automatically applied to products marketed online as 'CJC-1295 no DAC.'
Does CJC-1295 increase growth hormone?
Yes. Small human studies found sustained, dose-dependent increases in endogenous growth hormone after administration of the original long-acting CJC-1295 compound.
Does CJC-1295 increase IGF-1?
Yes. Human pharmacology studies found sustained increases in circulating IGF-1 after long-acting CJC-1295, including increases lasting beyond the immediate GH response.
Does CJC-1295 build muscle?
There is not strong clinical evidence establishing CJC-1295 as an effective muscle-building treatment. Human studies primarily measured GH and IGF-1 responses rather than validated gains in muscle mass or athletic performance.
Does CJC-1295 burn fat?
Fat-loss claims are common in online discussions, but published human CJC-1295 studies have not established it as an effective weight-loss or fat-loss treatment.
Why is CJC-1295 combined with Ipamorelin?
They are often discussed together because CJC-1295 acts through GHRH signaling while Ipamorelin acts through the ghrelin receptor. The popularity of the combination in online communities does not establish that the combination is safe or effective for physique, recovery, or anti-aging goals.
What are the side effects of CJC-1295?
The overall human safety profile is not well established. FDA has identified serious adverse events associated with CJC-1295 including increased heart rate and a systemic vasodilatory reaction. Compounded peptide products may also raise concerns involving immunogenicity, impurities, aggregation, and product characterization.
Is CJC-1295 banned by WADA?
Yes. CJC-1295 is specifically listed by WADA as a prohibited growth hormone-releasing factor and is prohibited at all times for athletes covered by WADA rules.
Is CJC-1295 measured in mg or mcg?
A vial may be labeled in milligrams, while smaller mathematical quantities can be expressed in micrograms. One milligram equals 1,000 micrograms.
How do you calculate CJC-1295 reconstitution concentration?
Divide the labeled vial amount by the liquid volume. For example, 2mg divided by 2mL equals 1mg/mL, which is also 1,000mcg/mL. This is concentration math rather than a recommendation for how CJC-1295 should be prepared.
Can the BACToBasics calculator handle CJC-1295 math?
Yes. Enter a labeled vial amount and liquid volume to calculate concentration, equivalent liquid volume, U-100 syringe units, and approximate amounts per vial. BACToBasics provides educational math rather than medical or dosing advice.
Sources & References
5 sourcesOpen the references when you want to inspect the research and regulatory sources behind this guide.
Sources & References
5 sourcesOpen the references when you want to inspect the research and regulatory sources behind this guide.
FDA states that available CJC-1295 clinical data are limited and identifies serious adverse events including increased heart rate and systemic vasodilatory reaction, along with peptide-quality and immunogenicity concerns.
Randomized human pharmacology studies of long-acting CJC-1295 in healthy adults. DOI: 10.1210/jc.2005-1536.
Human study examining growth-hormone pulsatility after administration of long-acting CJC-1295. DOI: 10.1210/jc.2006-1702.
Preclinical structural and pharmacologic work describing the albumin-binding design responsible for CJC-1295's prolonged activity. PMID: 15817669.
CJC-1295 is specifically listed under S2.2.4 growth hormone-releasing factors and is prohibited at all times for athletes subject to WADA rules.
BACToBasics provides educational information and math tools only. This content is not medical advice, dosing advice, injection instruction, or a recommendation to use any peptide or medication.